Dighiero G and Hamblin listed a prognostic classification for patients with chronic lymphocytic leukemia (CLL). This is based on reports by Oscier et al and Vasconcelos et al. The authors are from Institut Pasteur de Montevideo in Uruguay and the University of Southampton.
Parameters:
(1) 17p deletion (affecting p53)
(2) IGVH gene mutation
(3) Binet stage
del 17p |
IGVH mutation |
Binet Stage |
Survival in months (median) |
Management |
absent |
present |
A |
> 144 |
wait and watch |
absent |
present |
B or C |
120 |
wait and watch, or early treatment |
absent |
absent |
A |
97 |
wait and watch, or early treatment |
absent |
absent |
B or C |
78 |
early treatment |
present |
NA |
NA |
36 |
early treatment, consider unconventional treatment |
where:
• The "watch and wait" approaches to action if there is disease progression.
• Enrollment in a clinical trial should be considered if treatment is planned.
Specialty: Hematology Oncology
ICD-10: ,