Testing:
(1) baseline insulin in pmol/L (or µU/mL)
(2) insulin measured at constant intervals following administration of the oral glucose solution
area under each segment of time in pmol • min / L =
= ((concentration in pmol/L at start) + (concentration in pmol/L at end)) / 2 * (minutes in interval)
total area under the curve in pmol • min / L =
= SUM(area under all of the segments)
This total area can be adjusted for a variety of factors.
If we consider the baseline insulin as marking the patient's unstimulated state, then the insulin response to the glucose load is:
insulin response to glucose load in pmol • min/L =
= (total area under curve) - ((baseline insulin) * (total time in minutes))
Sometimes the insulin response is adjusted for the patient's body mass index (BMI).
insulin response adjusted for BMI in pmol•min•m^2 / (L • kg) =
= (area under curve in pmol•min/L) / (body mass index in kg per m^2)
