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Oral Eradication Therapy of Meliodosis with Trimethoprim-Sulfamethoxazole

Description

The oral eradication phase of treating meliodosis follows the initial intensive therapy phase. This is intended to prevent relapse caused by organisms in sequestered locations. The standard therapy during this phase is trimethoprim-sulfamethoxazole (TMP-SMX).


 

Duration: 3 to 6 months

 

Route: oral

 

Dosing internval: every 12 hours

Patient

Weight

Trimethoprim

Sulfamethoxazole

child

< 40 kg

8 mg per kg

40 mg per kg

adult

< 40 kg

1 x 160 mg

1 x 800 mg

NA

40 to 60 kg

3 x 80 mg

3 x 400 mg

NA

> 60 kg

2 x 160 mg

2 x 800 mg

 

where:

• The ratio of TMP to SMX in fixed dosage preparations is 1 to 5.

• The age range for a child is not given.

 


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