Filipovich et al developed criteria for the severity of chronic graft-versus-host disease (GVHD) for the National Institutes of Health. It is important to distinguish the various types of acute GVHD.
Patient selection: GVHD
Parameters:
(1) features of acute GVHD
(2) features of chronic GVHD
(3) number of days between donor lymphocyte infusion(initiating event) and onset of symptoms
Acute GVHD
Chronic GVHD
Days
Term
present
absent
<= 100 days
acute (classic)
present
absent
> 100 days
late-onset acute, persistent, recurrent
present
present
NA
overlap syndrome
absent
present
NA
chronic (classic)
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