Chronic exposure to vinyl chloride has been associated with development of a variety of hepatic tumors, some quite rare in the general population.
Hepatic tumors with good evidence for being associated with vinyl chloride exposure:
(1) angiosarcoma
(2) hemangiopericytoma
Hepatic tumors that may be associated with vinyl chloride (but not conclusive):
(1) hepatocellular carcinoma
(2) liver cell hyperplasia (diffuse or nodular)
(3) peliosis hepatis
Risk factors:
(1) prolonged exposure to vinyl chloride
(2) exposure to relatively high levels of vinyl chloride
(3) exposure to other hepatotoxins (ethanol, etc)
(4) possibly familial cancer risk
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Specialty: Toxicology, Emergency Medicine, Critical Care
