L Dopa Dosage | Total Levodopa Equivalents(LEDD) | Medical Algorithm

The total levodopa equivalent dose (levodopa equivalent daily dose, LEDD) can be calculated for a patient with Parkinson's disease (PD).

Parameters:

(1) dose of regular levodopa in mg

(2) dose of continuous release levodopa in mg

(3) dose of pramipexole in mg

(4) dose of ropinirole in mg

(5) dose of pergolide in mg

(6) dose of bromocriptine in mg

(7) therapy with tolcapone

Drug	Factor
regular levodopa	regular levodopa dose
continuous release levodopa	0.75 * (continuous release dose)
pramipexole	67 * (pramipexole dose)
ropinirole	16.67 * (ropinirole dose)
pergolide	100 * (pergolide dose)
bromocriptine	10 * (bromocriptine dose)
therapy with tolcapone	0.25 * ((factor for regular levodopa) + (factor for continuous release levodopa))

total equivalent daily dose in mg =

= SUM(all 7 factors)

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Total Levodopa Equivalents (Levodopa Equivalent Daily Dose, LEDD)