Zieve described a syndrome with hemolytic anemia in a patient who has had a heavy intake of alcohol.
Clinical features of Zieve's syndrome:
(1) hemolytic anemia
(2) jaundice
(3) alcoholic steatosis or steatohepatitis or cirrhosis
(4) hyperlipidemia
(5) recent history of heavy alcohol use
Other findings:
(5) abdominal pain
(6) fever
Complications:
(1) acute renal failure secondary to the hemoglobinuria
Melrose et al associated the hemolysis with an acquired pyruvate kinase deficiency in the red blood cells, resulting in osmotic fragility and autohemolysis.
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