Description

A focal dystonia can result in disability. Local injection of botulinum toxin may be followed by a favorable response which can be graded based on the scales of Gupta et al.


 

Parameters:

(1) disability rating scale (modified after Jancovic et al)

(2) maximal benefit (peak effect) after botulinum toxin injection

(3) side effects of botulinum toxin injection

(4) global rating scale

 

Severity of Spasm

Disability

Grade

none

none

0

slight (barely noticeable)

none

1

mild

none to slight

2

moderate

mild to moderate

3

severe

incapacitating

4

 

where:

• The modification of the scale of Jancovic et al was to add slight and mild to the disability column (before the levels were none, moderate and incapacitating).

 

Maximal Benefit After Injection (Peak Effect)

Functional Improvement

Grade

no effect

no change in function

0

mild improvement

no change in function

1

moderate improvement

no change in function

2

moderate improvement

moderate improvement

3

marked improvement

marked improvement

4

 

 

Side Effect

Grade

none

0

mild

1

disabling

2

 

global rating score =

= (grade of maximal benefit) - (grade of side effect)

 

Interpretation:

• A global rating scale >= 2 was considered a favorable response to local injection with botulinum toxin.

 


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