Features of Appel et al for Low-Risk Pediatric Lymphocyte-Predominant Hodgkin's Lymphoma (LPHL) That Requires Minimal Therapy

 

Features of a patient with Hodgkin's disease who can undergo minimal treatment:

(1) age < 22 years

(2) lymphocyte predominant Hodgkin's disease (LPHL)

(3) stage IA or IIA

(4) absence of B symptoms

(5) absence of bulky disease (nodal aggregate > 6 cm in diameter, mediastinal mass greater than one third of the thoracic diameter)

Status at Diagnosis	Initial Therapy	Less Than Complete Response
single lymph node	resection	AV-PC with or without IFRT
other	3 cycles AV-PC chemotherapy	IFRT

 

where:

• AV-PC is doxorubicin (Adriamycin), vincristine, prednisone and cyclophosphamide

• IFRT is involved field radiation therapy.