The minimum alveolar concentration of an anesthetic at 1 atmosphere that will result in immobilization of 50% of patients exposed to a noxious stimulus is called the MAC. Mapleson developed an equation to adjust the MAC for age. The authors is from the University of Wales.
Parameters:
(1) MAC for the anesthetic of a 40 year old adult, in percent
(2) age of the patient
MAC for an anesthetic in a patient in percent =
= (MAC for a person at 40 years)*(10^(-0.00269 * ((age)-40)))
MAC at age 40 for various anesthetics:
(1) halothane: 0.75%
(2) isoflurane: 1.17%
(3) enflurane: 1.63%
(4) sevoflurane: 1.80%
(5) desflurane: 6.6%
(6) nitrous oxide: 104%
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