Description

A patient with traumatic brain injury (TBI) may develop hyperthermia for a number of reasons. Identifying the cause is essential for effective therapy.


 

Drug-Related

Features

stimulant overdose (PCP, LDS, cocaine, amphetamine, methcathinone, etc)

febrile on admission; fever decreases as drug eliminated

neuroleptic malignant syndrome (NMS)

dopamine receptor blocking agents

malignant hyperthermia (MH)

exposure to halothane or depolarizing muscle relaxants during surgery

drug fever

antibiotics or other drugs; disappears on discontinuing drug

 

 

Brain Injury Related

Features

hypothalamic injury

 

paroxysmal autonomic instability with dystonia (PAID)

episodic, with diaphoresis, tachycardia, hypertonia, agitation; injury to thalamus and hypothalamus

 

 

Infection Related

Features

sepsis

positive blood cultures

pneumonia

pulmonary infiltrate, positive sputum cultures

meningitis

leukocytosis in CSF, positive CSF cultures

urinary tract infect

pyuria and positive urine culture

 


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