Clinical hypoaldosteronism represents a constellation of clinical and laboratory features that may be caused by a variety of disorders.
Clinical features of hypoaldosteronism:
(1) renal salt-wasting with dehydration
(2) hyperkalemia
(3) metabolic acidosis
Aldosterone receptor expression can be determined by testing peripheral mononuclear cells with competitive RT-PCR (Heering et al).
|
Serum Aldosterone |
Aldosterone Receptors |
Diagnosis |
|
elevated |
elevated |
mineralocorticoid resistance |
|
elevated |
normal |
mineralocorticoid resistance |
|
elevated |
decreased |
pseudohypoaldosteronism (with decreased receptors) |
|
normal |
elevated |
mineralocorticoid resistance |
|
normal |
normal |
mineralocorticoid resistance |
|
normal |
decreased |
pseudohypoaldosteronism (with decreased receptors) |
|
decreased |
elevated |
true hypoaldosteronism |
|
decreased |
normal |
true hypoaldosteronism |
|
decreased |
decreased |
mixed hypoaldosteronism |
where:
• Mineralocorticoid resistance may be due to a qualitative defect in the receptor, receptor blockade (for example by autoantibody), drug interference or other cause.
Specialty: Endocrinology, Clinical Laboratory, Nephrology, Cardiology
ICD-10: ,
