Benton et al developed the Cutaneous Lymphoma International Prognostic Index (CLIPi) for a patient with mycosis fungoides or Sezary syndrome. One model deals with early stage disease. The authors are from Guy's and St. Thomas' NHS Foundation Trust, King's College London, MD Anderson Cancer Center and Integrated Cancer Research (ICARIS) UK.
Patient selection: mycosis fungoides or Sezary syndrome, early stage
Early stage disease: T1/T2 AND Nx/N0/N1 AND M0
Late stage disease: T3/T4 OR N2/N3 OR M1
Outcome: 10 year overall survival (OS)
Parameters:
(1) gender
(2) age in years
(3) cutaneous plaques
(4) folliculotropic disease
(5) N stage
Parameter
Finding
Points
gender
female
0
male
1
age in years
<= 60 years
0
> 60 years
1
plaques
absent
0
present
1
folliculotropic disease
absent
0
present
1
N stage
N0
0
N1 or Nx
1
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the worse the prognosis.
Score
Risk Group
10 Year OS
0 or 1
low
90%
2
intermediate
76%
3 to 5
high
49%
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