The International Agranulocytosis and Aplastic Anemia Study defined criteria for agranulocytosis.
Criteria - both of the following:
(1) absolute neutrophil count < 500 per µL ( < 0.5 * 10^9/L) on 2 separate blood counts
(2) one or more of the following:
(2a) fever
(2b) clinical infection
(2c) clinical signs of septic shock (chills and sweating, hypotension, confusion)
where:
• I would also think that repeated positive blood cultures for a pathogen (bacteremia or fungemia) might also qualify, although that would constitute a clinical infection.
• I will use > 38.3°C (101 °F) to define fever in the spreadsheet.
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