Campiotti et al studied patients with chronic myeloid leukemia (CML) who developed blast crisis. The authors are from Clinica Universita dell’Insubria and Ospedale di Circolo Varese in Italy.
Patient selection: chronic myeloid leukemia
Criteria for blast crisis – one or more of the following:
(1) blasts >= 20% of nucleated bone marrow cells
(2) blasts >= 20% of differential count in peripheral blood
(3) extramedullary blast proliferations
(4) large blast islands in the bone marrow
where:
• Alimena et al used counts >= 30% rather than >= 20%.
Criteria for CML blast crisis rather than AML: presence of t(9;22)(q34;q11)
Some patients may initially present in blast crisis, making the distinction from AML more important.
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