Synonym: Miller-Fisher Syndrome, MFS
Presentation: diplopia followed by ataxia in a few days
Major diagnostic criteria:
(1) history of recent antecedent infection
(2) complex ophthalmoplegia without nystagmus
(3) gait and limb ataxia
(4) areflexia
(5) muscle weakness ranges from none to mild
(6) sensory loss in distal limbs tends to be mild
Other features:
(1) Speech is not affected.
(2) Ptosis is present and usually mild.
(3) The pupillary light response is spared.
Laboratory findings:
(1) elevated CSF protein without significant pleocytosis
Electrodiagnostic findings:
(1) sensory and motor conduction velocities are normal
(2) sensory nerve action potentials show decreased amplitude, with eventual return to normal
