7q11.23 is the locus affected by the Williams-Beuren microdeletion syndrome.
Clinical findings:
(1) speech delay
(2) language delay
(3) variable developmental delay
(4) variable mental retardation
(5) deficits in social interaction skills including autism-spectrum disorder
(6) variable behavioral problems
(7) hypotonia in the neonatal period
(8) variable joint laxity
(9) mild dysmorphic facial features
(9a) high broad nose
(9b) thin upper lip and/or short philtrum
(9c) broad forehead
(9d) low set ears and/or posterior rotation
(9e) hypertelorism
(9f) straight eyebrows
(9g) variable cleft palate
(10) variable congenital anomalies (congenital heart disease, vertebral anomalies, genitourinary anomalies, etc)
