Hemorrhagic disease of the newborn (HDNB) may first be recognized when a neonate or infant presents with unexpected bleeding.
Clinical features:
(1) unexpected bleeding
(2) presence of risk factors for HDNB
(3) prolonged PT (> 1.5 times normal control), normal plasma fibrinogen and normal platelet count
(4) exclusion of other diagnoses
(5) response to vitamin K administration
Types of unexpected bleeding:
(1) gastrointestinal bleeding (hematemesis, melena)
(2) intracranial hemorrhage (subdural hematoma, other)
(3) skin bruising
(4) epistaxis
(5) intra-ocular hemorrhage
(6) hemothorax
(7) umbilical cord bleeding
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Specialty: Hematology Oncology, Clinical Laboratory, Nutrition, Pharmacology, clinical, Pedatrics
ICD-10: ,
