Episodic angioedema with eosinophilia (EAE, Gleich's Syndrome) is a recurrent condition with an uncertain causation. It may be related to the release of cytokines from activated T helper cells.
Clinical findings:
(1) recurrent episodes of angioedema and/or urticaria
(2) weight gain during the episodes (due to fluid retention)
(3) fever
(4) pruritis
(5) oliguria
Laboratory findings:
(1) leukocytosis with marked eosinophilia
(2) elevated serum IgM
(3) elevated serum IgE
(4) elevated serum IL-5
Diagnosis requires exclusion of other causes of eosinophilia (collagen vascular disease, parasitic infection, malignancy, atopy, etc).
The absence of central organ involvement is an essential feature that distinguishes it from the more serious forms of the hypereosinophilic syndrome (HES).
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