Lightfoot et al diagnosed polyarteritis nodosa (PAN) using classification and regression tree (CART) analysis. This was included with the 1990 American College of Rheumatology criteria for PAN.
|
Top Level |
Second Level |
Third Level |
Fourth Level |
Diagnosis |
|
arteriography positive |
neuropathy positive |
biopsy positive |
|
PAN |
|
arteriography positive |
neuropathy positive |
biopsy negative |
weight loss > 6.5 kg |
PAN |
|
arteriography positive |
neuropathy positive |
biopsy negative |
weight loss < 6.5 kg |
no PAN |
|
arteriography positive |
neuropathy negative |
|
|
no PAN |
|
arteriography negative |
either AST or ALT abnormal |
|
|
PAN |
|
arteriography negative |
both AST and ALT normal |
male sex |
|
PAN |
|
arteriography negative |
both AST and ALT normal |
female sex |
|
no PAN |
Surrogate data if arteriography data is not available:
(1) vessel biopsy normal or abnormal
(2) testicular pain or tenderness present or absent
Surrogate data if vessel biopsy not available:
(1) livedo reticularis present or absent
(2) diastolic blood pressure > 90 mm Hg or not
|
Patient Subsets |
Findings |
|---|---|
|
PAN patients |
neuropathy and weight loss > 6.5 kg; negative arteriogram and artery biopsy |
|
|
positive artery biopsy and neuropathy; negative arteriogram |
|
|
positive arteriogram; male sex; normal AST and ALT |
|
|
positive arteriogram; abnormal AST or ALT |
|
non-PAN patients |
negative arteriogram and no neuropathy |
|
|
neuropathy; negative arteriogram and artery biopsy; weight loss <= 6.5 kg |
|
|
positive arteriogram; normal AST and ALT; female sex |
where:
• AST = aspartate aminotransferase (SGOT)
• ALT = alanine aminotransferase (SGPT)
Purpose: To diagnose Polyarteritis nodosa using a classification tree.
Specialty: Immunology/Rheumatology
Objective: criteria for diagnosis, differential diagnosis and mimics, red flags
ICD-10: M30,
