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Approved Indications for the Use of Etanercept (Enbrel)

Description

Etanercept (Enbrel) has been approved for use in a number of autoimmune disorders. Therapy with etanercept is expensive and may have adverse effects, so it should only be used when there is a clear indication. It is usually considered after there has been a failure of first-line therapy.


 

Mechanism of action: antagonist to tumor necrosis factor alpha (TNF)

Disorder

Qualifiers

rheumatoid arthritis

moderate to severe AND active

polyarticular juvenile arthritis

moderate to severe AND >= 2 years of age AND (rheumatoid or idiopathic)

psoriasis

moderate to severe AND chronic AND problem with first-line therapy (unresponsive, economics, etc)

psoriatic arthritis

moderate to severe

ankylosing spondylitis

moderate to severe AND active

 

Goals of therapy may include:

(1) to induce a major clinical response

(2) to reduce progression in structural damage

(3) to improve physical function (and to reduce disability)

 

Key contraindications:

(1) active infection

(2) serious allergic reaction to etanercept or to an additive in the product

 


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Specialty

ICD-10