Browne and Holland reported a number of infections associated with the presence of certain anticytokine autoantibodies.
Anticytokine Autoantibody |
Associated Infection |
anti-GM-CSF (granulocyte monocyte colony stimulating factor) |
Nocardia, Aspergillus, Histoplasma, Cryptococcus, Proteus |
anti-interferon gamma |
nontuberculous myobacteria |
anti-interferon alpha |
viral infection |
anti-IL6 (interleukin 6) |
Staphylococcus aureus |
anti-IL17 |
mucocutaneous candidiasis |
anti-IL22 |
mucocutaneous candidiasis |
anti-TNF (tumor necrosis factor) |
Gram negative infection |
The possibility of anticytokine autoantibodies should be considered in a person with an infection if:
(1) unusual pathogen or unusual severity or recurrent (suspicion for an immunodeficiency)
(2) absence of other explanation
Purpose: To identify an infection associated with anticytokine autoantibodies.
Specialty: Immunology/Rheumatology, Infectious Diseases
Objective: laboratory tests, criteria for diagnosis
ICD-10: M01, M02, M03,