Song et al used a modified version of the score of Pimpinelli et al to identify a patient with early Mycosis Fungoides (MF). The authors were participants at the 2011 Society for Hematopathology and European Association for Haematopathology Workshop.
Parameters:
(1) clinical features
(2) histpathologic features
(3) molecular feature (clonal T-cell receptor gene rearrangement)
(4) immunophenotypic features
Clinical features:
(1) progressive and/or persistent patches and/or thin plaques
(2) location in non-sun-exposed skin
(3) variation in size and shape present
(4) poikiloderma
Histopathologic features:
(1) superficial lymphoid infiltrate
(2) epidermotropism without spongiosis
(3) lymphoid atypia
Immunophenotypic features:
(1) CD7 positive cells < 10%
(2) T-cell antigen loss confined to the epidermis
(3) (percent T cells CD2 positive < 50%) OR (percent T cells CD3 positive < 50%) OR (percent T cells CD5 positive < 50%) = loss of one or more pan-T-cell markers
Paramter |
Finding |
Points |
clinical |
(feature 1) + (2 or 3 of items 2 to 4) |
2 |
|
(feature 1) + (1 of items 2 to 4) |
1 |
|
any other combination |
0 |
histopathology |
(feature 1) + (both 2 and 3) |
2 |
|
(feature 1) + (either 2 or 3) |
1 |
|
any other combination |
0 |
clonal T cell receptor |
present |
1 |
|
absent |
0 |
immunophenotype |
>= 1 immunophenotypic features |
1 |
|
0 immunophenotypic features |
0 |
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score 6
• A score >= 4 is diagnostic for early Mycosis Fungoides.
Specialty: Hematology Oncology, Dermatology
ICD-10: ,