Simplified Prognostic Score of Bierman et al for a Patient with Advanced Hodgkin's Disease Following Autologous Hematopoietic Stem Cell Transplantation (HSCT)
Bierman et al reported a prognostic score for a patient with advanced Hodgkin's disease who is receiving an autologous hematopoietic stem cell transplant. This is derived from the International Prognostic Index. The authors are from the University of Nebraska.
Patient selection: advanced Hodgkin's disease, receipt of an autologous hematopoietic stem cell transplant
Parameters:
(1) serum albumin in g/dL
(2) hemoglobin
(3) age in years
(4) lymphocytopenia (absolute count < 600 per µL OR < 8% of differential count)
Parameter
Finding
Points
serum albumin
>= 4 g/dL
0
< 4 g/dL
1
hemoglobin
>= 10.5 g/dL
0
< 10.5 g/dL (anemia)
1
age in years
< 45 years
0
>= 45 years
1
lymphocytopenia
absent
0
present
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the prognosis.
Median Overall Survival (OS) in Years
Score
Median OS Primary Refractory
Median OS First Relapse
Median OS 2nd+ Relapse
0
7.4 years
8.3 years
not reached
1
4.8 years
10.3 years
4.8 years
2
1.6 years
4.2 years
5.0 years
>= 3
0.8 years
2.1 years
2.1 years
To read more or access our algorithms and calculators, please log in or register.
