Score of Makharia et al for Distinguishing Between Crohn's Disease and Intestinal Tuberculosis

Description

Crohn's Disease needs to be distinguished from intestinal tuberculosis, especially in developing countries. Makharia et al developed a simple equation to aid in differentiating these 2 conditions. The authors are from All India Institute of Medical Sciences in New Delhi.

Parameters:

(1) involvement of the sigmoid colon

(2) blood in the stool

(3) weight loss (amount of loss not specified)

(4) focally enhanced colitis

Parameter	Finding	Points
involvement of the sigmoid colon	absent	0
	present	-2.5
blood in the stool	absent	0
	present	-2.1
weight loss	absent	0
	present	2.3
focally enhanced colitis	absent	0
	presnet	-2.1

where:

• Weight loss is associated with intestinal tuberculosis, while the remaining parameters are not.

score =

= SUM(points for the 4 parameters) + 7

Interpretation:

• minimum score: 0.3 (the addition of 7 is to avoid a negative number)

• maximum score: 9.3

• A score >= 5.1 indicates intestinal tuberculosis. To obtain this score there are 5 patterns: (1) weight loss only; (2) weight loss and sigmoid colon involvement; (3) weight loss and blood in stool, (4) weight loss and focally enhanced colitis, (5) weight loss and both blood in stool and focal colitis.

Performance:

• The area under the ROC curve is 0.91.

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Score of Makharia et al for Distinguishing Between Crohn's Disease and Intestinal Tuberculosis

Description

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