Patient selection: thiazide therapy (in population of Chinese)
Criteria for thiazide-associated hyponatremia:
(1) plasma sodium < 130 mmol/L
(2) current thiazide use at presentation
(2) resolution after discontinuation of thiazide therapy
(3) absence of alternative explanations
Risk factors for hyponatremia in a patient taking thiazides:
(1) older age (adjusted odds ratio 2.1 for each 10 years older, with mean age > 70 years)
(2) body weight (adjusted odds ratio 0.73 for each 5 kg increase)
(3) hypokalemia (adjusted odds ratio 0.37 for each 1 SD increase)
where:
• Mean body weight for patients with hyponatremia 52.3 kg, upper limit (+1 SD) 62.6.
• Mean body weight for controls 63.4 kg, lower limit (-1 SD) 49.7.
• Mean plasma potassium for patients with hyponatremia 3.4 mmol/L, upper limit (+1 SD) 4.3.
• Mean plasma potassium for controls 4,0 mmol/L, lower limit (-1 SD) 3.4.
