A prognostic score based on 7 independent risk factors can be used to assess patients with advanced Hodgkin's disease. This can help decide the therapeutic regimen to use in treatment.
Parameters:
(1) serum albumin
(2) hemoglobin
(3) patient's gender
(4) patient's age
(5) stage of Hodgkin's disease
(6) white blood cell (WBC) count
(7)lymphocyte count: absolute or percent of differential
Parameter
Finding
Points
serum albumin
>= 4 g/dL
0
< 4 g/dL
1
hemoglobin
>= 10.5 g/dL
0
< 10.5 g/dL
1
gender
female
0
male
1
age
< 45
0
>= 45
1
stage of disease
I, II. III
0
IV
1
white blood cell count
< 15,000 per µL
0
>= 15,000 per µL
1
lymphocyte count
>= 600 per µL, AND >= 8% of differential
0
< 600 per µL, OR < 8% of differential
1
(Table 2, page 1510)
prognostic score =
= SUM(points for 7 parameters)
Interpretation:
• minimum score: 0
• maximum score: 7
• low risk: <= 2
• moderate-to-high risk: >= 3
• patients at very high risk: not identified by model
Score
Freedom from Disease Progression at 5 Years
Overall Survival at 5 Years
0
82%
88%
1
77%
90%
2
66%
83%
3
60%
80%
4
50%
70%
>= 5
40%
52%
(Figure 1, page 1511)
To read more or access our algorithms and calculators, please log in or register.
