Prognostic Factors of Horning et al for a Patient Undergoing an Autologous Stem Cell Transplant for Recurrent or Refractory Hodgkin's Disease (Stanford Prognostic Index)
Horning et al reported prognostic factors for a patient with recurrent or refractory Hodgkin's disease undergoing autologous stem cell transplantation. These can help to identify a patient who may require more aggressive management. The authors are from Stanford University.
Patient selection: recurrent or refractory Hodgkin's disease
Management: high-dose chemotherapy and autologous hematopoietic progenitor (stem) cell transplantation
Parameters:
(1) systemic symptoms at relapse
(2) (disseminated pulmonary Hodgkin's disease) OR (bone marrow disease) at relapse
(3) disease activity at time of transplantation
Parameter
Finding
Points
systemic symptoms
absent
0
present
1
lung or BM at relapse
no
0
yes
1
disease activity
none or minimal
0
more than minimal
1
score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the overall survival.
Systemic Symptoms
Lung or BM Involvement
Disease Activity
Overall Survival
absent
absent
none/minimal
77%
present
absent
absent
64%
absent
present
absent
62%
absent
absent
present
56%
present
present
absent
45%
present
absent
present
38%
absent
present
present
35%
present
present
present
17%
where:
• The data for overall survival is from Table 6. The duration of the overall survival is not stated. It may be 3-year.
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