PRODIGY Score of Khanna et al for Prediction of Opioid-Induced Respiratory Depression

Description

Khanna et al reported the PRODIGY score to identify a patient at increased risk for opioid-induced respiratory depression. This can help to identify a patient most likely to benefit from closer monitoring. The authors are from PRODIGY Group Collaborators.

PRODIGY = Prediction of Opioid-Induced respiratory depression in patients monitored with capnography

Patient selection: opioid-analgesia

Parameters:

(1) age in years

(2) sex

(3) opioid naive

(4) sleep disorder (obstructive sleep apnea, other)

(5) chronic heart failure

Parameter	Finding	Points
age in years	< 60 years	0
	60 to 69.99	8
	70 to 79.99	12
	>= 80 years	16
sex	female	0
	male	8
opioid naive	no	0
	yes	3
sleep disorder	no	0
	yes	5
chronic heart failure	no	0
	yes	7

total score =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0

• maximum score: 39

• The higher the score the greater the risk of opioid-related respiratory depression.

Score	Risk Group	Percent with Respiratory Depression
0 to 7	low	24%
8 to 14	intermediate	42%
>= 15	high	65%

Performance:

• The area under the ROC curve was 0.83. The sensitivity, specificity, PPV and NPV are less impressive.

To read more or access our algorithms and calculators, please log in or register.