Fecal microbiota transplantation can be effective therapy of recurrent Clostridioides difficile disease. Tariq et al identified factors associated with failure of the transplant. The authors are from the Mayo Clinic, Rochester General Hospital and University of Oklahoma.
Patient selection: fecal transplant for recurrent Clostridioides difficile
Outcome: failure of transplant to stop the C. difficile disease
Frequency of transplant failure: 17%
Predictors of transplant failure:
(1) non-C. difficile antibiotics after transplant
(2) presence of inflammatory bowel disease
(3) poor quality of bowel preparation prior to transplant
(4) C. difficile related hospitalization before fecal transplant
(5) inpatient fecal transplant
(6) severe C. difficile disease
The risk of transplant failure increases with the number of risk factors present. The chances of success can be increased by addressing the modifiable factors.
