Qayed et al reported disease disk indices for pediatric patients undergoing allogeneic hematopoietic cell transplantation. One index applies to acute myeloid leukemia (AML) and another to acute lymphoblastic leukemia (ALL). The authors are from multiple institutions in the United States and Columbia.
Patient selection: pediatric patient with acute myeloid leukemia (AML), receiving an allogeneic hematopoietic cell transplant
Parameters:
(1) age in years
(2) disease status, including minimal residual disease (MRD)
(3) cytogenetic risk
Parameter
Finding
Points
age of the patient
<3 years old
2
>= 3 years old
0
disease status
first complete remission
0
>= 2nd complete remission, MRD negative
0
>= 2nd complete remission, MRD positive
3
not in remission
5
cytogenetic risk
favorable
0
intermediate
5
poor
5
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 12
• The higher the score the greater the risk.
Total Score
Prognostic Group
5-Year Overall Survival
0
low risk (good)
80%
2 to 5
intermediate risk
64%
7 or 8
high risk
50%
10 or 12
very high risk
33%
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