Rodriguez et al reported 2 scores for screening an adult for non-alcoholic fatty liver disease (NAFLD) based on practical clinical measures. This can help to identify a patient who may benefit from a more complete evaluation. The authors are from the University of California San Francisco, University of California Berkley, Wake Forest University and University of California San Diego.
Patient selection: age 44 to 84 years
Parameters:
(1) body mass index (BMI) category
(2) sex
(3) cigarette smoking history
(4) age category
(5) type 2 diabetes
(6) race/ethnicity
(7) serum GGT in U/L
(8) fasting serum triglycerides in mg/dL
BMI
White
AA
Hispanic
Chinese
normal
< 25
< 25
< 25
< 23
overweight
25 to 29.99
25 to 29.99
25 to 29.99
23 to 27.49
obesity 1
30 to 34.99
30 to 34.99
30 to 34.99
>= 27.5
obesity 2
>= 35
>= 35
>= 35
Parameter
Finding
Points
BMI categories
normal
0
overweight
3
obesity grade 1
5
obesity grade 2
6
sex
female
2
male
0
cigarette smoking
never
2
former
1
current
0
age category
44 to 64 years
5
65 to 74 years
4
75 to 84 years
0
type 2 diabetes
no
0
yes
1
race/ethnicity
White
3
African American
0
Hispanic
3
Chinese American
3
serum GGT
< 5 U/L (first quartile)
0
5 to 7.9 (second quartile)
2
8 to 13.9 (third quartile)
4
>= 14 U/L (fourth quartile)
5
serum triglycerides
< 75 mg/dL
0
75 to 149 mg/dL
5
>= 150 mg/dL
6
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 29
• A score >= 22 has a sensitivity of 75%, specificity of 72% and post-test probability of > 8%.
Performance:
• The area under the ROC curve is 0.83 for validation and 0.80 for validation cohorts.
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