Nomograms of Kawai et al for a Patient with Stage IV Colorectal Cancer After Curative Resection: Overall Survival (OS)

Description

Kawai et al reported two nomograms for a patient with Stage IV colon cancer who has undergone a curative resection. One nomogram predicts overall survival (OS). The authors are from The University of Tokyo and Tokyo Medical and Dental University in Japan.

Patient selection: stage IV colon cancer after curative resection

Outcome: 5-year disease-free survival

Parameters:

(1) serum CEA after surgery in ng/mL

(2) T status

(3) N status

(4) peritoneal dissemination (localized adjacent to primary is P1, limited distant metastasis is P2 and diffuse metastases is P3)

LOG10(CEA)	Points
0 to 0.5	49.996 * LOG10(CEA)
0.5 to 4.0	(20.782 * LOG10(CEA)) + 16.532
> 4.0	100

Parameter	Finding	Points
T status	T1, T2, T3	0
	T4	24
N status	N0	0
	N1	24
	N2a	37
	N2b	81
peritoneal dissemination	none	0
	P1 or P2	50
	P3	97

total score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: 0

• maximum score: 300

• The higher the score the worse the overall survival.

Total Score	5-year Overall Survival
< 20	> 70%
20 to 194	0.78532 - (0.0035865 * (score))
> 194	< 10%

Performance:

• The area under the ROC curve is 0.64 in the derivation and the validation sets.

To read more or access our algorithms and calculators, please log in or register.

Nomograms of Kawai et al for a Patient with Stage IV Colorectal Cancer After Curative Resection: Overall Survival (OS)

Description

Specialty