Macrophagic myofasciitis (MMF) is a clinical disorder of certain etiology with clinical findings that overlaps with chronic fatigue and fibromyalgia.
Clinical features (MMF-associated clinical syndrome):
(1) chronic fatigue
(2) arthromyalgias (musculoskeletal pain)
(3) variable mild cognitive dysfunction
(4) variable psychiatric manifestations
(5) variable headaches
(6) variable neurologic findings
A muscle biopsy shows a specific histologic appearance:
(1) focal inflammatory infiltrate rich in macrophages, located epi/peri/endo-mysial
(2) presence of T-cells
(3) absence of significant myofiber injury
Complications:
(1) chronic disability
(2) misdiagnosis of a psychosomatic disorder
One hypothesis is that it is an immune response to aluminum hydroxide or other adjuvants used in vaccines.
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Specialty: Surgery, orthopedic
