A patient with antiphospholipid syndrome (aPL) may develop complications within intra-abdominal organs. The presence of aPL should be considered when these conditions are encountered in clinical practice.

Hepatic complications of hypercoagulable state:

(1) Budd-Chiari syndrome

(2) hepatic vein thrombosis including hepatic veno-occlusive disease

(3) hepatic infarction

(4) portal hypertension

(5) hepatic artery thrombosis in transplanted liver


Hypercoagulable complications in other intra-abdominal organs:

(1) acute pancreatitis

(2) splenic infarction

(3) functional asplenia (autosplenectomy)

(4) intestinal ischemia with angina and/or ischemia/infarction

(5) intestinal bleeding


The catastrophic antiphospholipid syndrome may be associated with widespread thrombosis in multiple organs.


A patient with one of these conditions may have aPL:

(1) nodular regenerative hyperplasia

(2) autoimmune hepatitis

(3) biliary cirrhosis

(4) inflammatory bowel disease

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