Ma et al reported the immune risk score for evaluating a patient with diffuse large B-cell lymphoma (DLBCL). The authors are from Sun Yat-sen University, State Key Laboratory of Oncology in South China and Imperial College London.
Patient selection: diffuse large B-cell lymphoma
Parameters:
(1) percentage of memory B cells
(2) percentage of follicular helper T cells
(3) percentage of gamma/delta T cells
(4) percentage of resting NK cells
(5) percentage of M0 macrophages
(6) percentage of M1 macrophages
(7) percentage of M2 macrophages
(8) percentage of eosinophils
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Parameters
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Points
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percentage of memory B cells
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1.488* (percent)
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percentage of follicular helper T cells
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-2.083 * (percent)
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percentage of gamma/delta T cells
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-3.128* (percent)
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percentage of resting NK cells
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5.456* (percent)
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percentage of M0 macrophages
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-2.619* (percent)
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percentage of M1 macrophages
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6.429* (percent)
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percentage of M2 macrophages
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3.951* (percent)
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percentage of eosinophils
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15.420* (percent)
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where:
• Percent may refer to the decimal fraction from 0 to 1 or a number from 0 to 100. The assumption is that it is a decimal fraction based on the cut-off below.
total score =
= SUM(points for all of the parameters)
Interpretation:
• A score <= 0.45 indicates low-risk. The 5-year survival was 67%.
• A score > 0.45 indicates high-risk. The 5-year survival was 23%.
