Graus et al reported criteria for the diagnosis of various types of autoimmune encephalitis. The diagnosis of autoimmune encephalitis may correlate with the type of autoantibody that the patient has. The authors are from multiple institutions from around the world.
Syndrome
Autoantibody
limbic encephalitis
Hu (aka ANNA1)
Ma2
GAD
AMPA receptor
GABA-B receptor
LGl1
CASPR2
Amphiphysin
CV2 (CRMP5)
encephalitis
GABA-A receptor
mGluR5
DPPX
AQP4
anti-NMDA receptor encephalitis
NMDA receptor
basal ganglia encephalitis
dopamine-2 receptor
Bickerstaff's brainstem encephalitis
CQ1b
acute disseminated encephalomyelitis
MOG
Morvan encephalitis
CASPR2
Antibody
Name
Underlying Tumor(s)
Hu (ANNA1)
small cell lung
Ma2
testicular
GAD
glutamic acid decarboxylase
thymoma, small cell lung
AMPA receptor
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
thymoma, small cell lung
GABA-B receptor
small cell lung
LGl1
leucine-rich glioma inactivated 1
thymoma
CASPR2
contactin associated protein 2
thymoma
Amphyphysin
small cell lung
CV2/CRMP5
collapsin response mediator protein
small cell lung
GABA-A receptor
small cell lung
mGluR5
metabotropic glutamate receptor 5
Hodgkin's
DPPX
dipeptidyl-peptidase-like protein-6
lymphoma
AQP4
Aquaporin 4
NMDA receptor
N-methyl-D-Aspartate
ovarian teratoma
Dopamine-2 receptor
CQ1b
MOG
myelin oligodendrocyte glycoprotein
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