A patient with sickle cell disease (SCD) may have antiphospholipid antibodies which can contribute to hypercoagulability.
Patient selection: sickle cell disease (SCD)
When to suspect antiphospholipid antibodies:
(1) venous thrombosis
(2) ischemic stroke
(3) leg ulceration
(4) major cardiac event
Testing should include serial monitoring of:
(1) lupus anticoagulant
(2) IgG anticardiolipin antibodies (aCL)
Reporting of antiphospholipid antibodies should be in titers so that the level of activity can be followed over time.
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Specialty: Hematology Oncology
