Yellow Fever Vaccine-Associated Viscerotropic Disease (YEL-AVD, Postvaccinal Multiple Organ Failure)

A rare but serious complication of the yellow fever vaccine is Yellow Fever Vaccine-Associated Viscerotropic Disease (YEL-AVD).

Synonym: postvaccinal multiple organ failure (MOF)

Onset: 2-5 days after the vaccination

Clinical features:

(1) fever

(2) respiratory failure

(3) neurotropic disease (encephalitis)

(4) renal failure

(5) jaundice

Laboratory features:

(1) elevated liver function tests

(2) pancytopenia

The disease may range from moderate to severe and it can be fatal.

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