Criteria for Wegener's granulomatosis were proposed at an International Consensus Conference held at the University of North Carolina, Chapel Hill, North Carolina.
Lesion: necrotizing and granulomatous vasculitis
Vessel
Involvement
venules
yes
capillaries
yes
arterioles
yes
small arteries
yes
medium-sized arteries
yes
large arteries
no
Clinical features:
(1) granulomatous inflammation of the lung
(2) necrotizing glomerulonephritis
(3) presence of cANCA (rarely pANCA)
(4) no or scant immune deposits on immunofluoresence
Differential diagnosis:
(1) microscopic polyangiitis
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