Pulmonary-Renal Vasculitic Syndrome | Differential Diagnosis

Vasculitis

Clinical Findings

Laboratory Findings

Histologic Findings

Churg-Strauss syndrome

asthma

eosinophilia, pANCA positive

eosinophil-rich granulomatous vasculitis; no or rare immune deposits

cryoglobulinemia

skin rash, arthralgias

ANCA negative, serum cryoglobulins

granular immune deposits with cryoglobulin

drug-associated vasculitis

drug exposure, skin rash, arthralgias

pANCA and/or cANCA positive

granular immune deposits

Goodpasture's syndrome

pulmonary hemorrhage

anti-GBM antibody in serum

linear immune deposits with anti-GBM

Henoch-Schonlein purpura

arthralgias, skin rash, abdominal pain

ANCA negative

granular immune deposits with IgA

microscopic polyangiitis

skin rash, arthralgias

pANCA and/or cANCA positive

necrotizing vasculitis; no or rare immune deposits

serum sickness

history of exposure to serum

ANCA, RF and ANA negative

granular immune deposits with IgM, IgG and complement

systemic lupus erythematosus (SLE)

skin rash, photosensitive, arthralgias

ANA positive; ANCA negative

granular immune deposits with IgM, IgG and complement

Wegener's granulomatosis

rhinitis or sinusitis, rash, arthralgias

cANCA positive

necrotizing and granulomatous vasculitis; no or rare immune deposits