Rassenti et al evaluated patients with chronic lymphocytic leukemia (CLL) for the relationship between ZAP-70 and immunoglobulin heavy chain gene mutation (IgVH) status and therapy-free survival. This can help identify patients with more aggressive disease who may require closer monitoring and more aggressive management. The authors are from the Chronic Lymphocytic Leukemia Research Consortium.
ZAP-70 is an intracellular tyrosine kinase involved in T-cell receptor signaling.
Parameters:
(1) ZAP-70 status (positive vs negative)
(2) mutations of the immunoglobulin heavy chain gene mutation (IgVH)
ZAP-70
IgVH Gene Mutations
Percent without Therapy at 5 Years
Percent without Therapy at 10 Years
positive
none
20%
0%
positive
present
34%
18%
negative
none
65%
26%
negative
present
92%
52%
from Figure 4, page 900
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