Use of Perinuclear Antineutrophil Cytoplasmic Autoantibodies (pANCA) and Anti-Saccharomyces cerevisiae Mannan Antibodies in Evaluating a Patient with Idiopathic Inflammatory Bowel Disease (IBD)
Testing for perinuclear antineutrophilc cytoplasmic autoantibodies (pANCA) and antibodies to Saccharomyces cerevisiae mannan (SCM) can be helpful in diagnosing idiopathic inflammatory bowel disease (IBD).
Test Results
Crohn’s Disease
Ulcerative Colitis
non-IBD GI Disease
pANCA positive
15%
66%
8%
antibodies to SCM positive
61%
12%
11%
pANCA positive, antibodies to SCM negative
3%
58%
NA
pANCA negative, antibodies to SCM positive
49%
3%
NA
pANCA positive, antibodies to SCM positive
NA
NA
NA
Limitations:
• About a third of each category will test negative for its “target” antibody.
• About 10% of each category will test positive for the “target” antibody for the other category..
• Disease activity will impact the intensity of the immune response.
• Thus the results are supportive of a diagnosis but must be used in context with other findings.
To read more or access our algorithms and calculators, please log in or register.
