Osetlamivir (Tamiflu) is an oral drug that can be used to treat or prevent influenza A or B.
Indications:
(1) age >= 1 year of age for treatment and >= 13 years for prophylaxis
(2) influenza A or B
Dosing forms:
(1) 75 mg capsules
(2) oral pediatric suspension with 12 mg/mL (25 mL with 300 mg)
Dosing in children:
(1) by the table below (from the PDR)
(2) 2 mg per kg up to a maximum of 75 mg
(3) for prophylaxis in child >= 13 years, one 75 mg capsule
|
Pediatric Body Weight |
Dose |
Volume Suspension |
|
<= 15 kg |
30 mg |
2.5 mL |
|
15.01 to 23 kg |
45 mg |
3.75 mL |
|
23.01 to 40 kg |
60 mg |
5.0 mL |
|
> 40 kg |
75 mg |
6.25 mL |
Dosing is reduced when the creatinine clearance is 10 - 30 mL per minute. No dosing recommendations are made for creatinine clearance < 10 mL/min or for patients receiving dialysis.
|
Purpose |
Creatinine Clearance |
Number of Daily Doses |
|
prophylaxis |
> 30 mL per min |
1 |
|
treatment |
> 30 mL per min |
2 |
|
prophylaxis |
10 - 30 mL/min |
0.5 |
|
treatment |
10 - 30 mL/min |
1 |
where:
• A half dose may be 30 mg as a suspension a day or 1 pill every other day.
|
Duration of Treatment |
Days of Treatment |
|
prophylaxis |
duration of exposure (at least 7 days) |
|
treatment |
5 |
Specialty: Infectious Diseases, Pharmacology, clinical
