Description

Kyle et al identified unfavorable prognostic factors for long-term survival in patients with primary amyloidosis. These can help identify patients who may require more aggressive management and closer monitoring. The authors are from the Mayo Clinic.


 

The chance of survival >= 10 years was about 5%.

 

Unfavorable prognostic factors for long term survival (>= 10 years):

(1) older age at the time of diagnosis

(2) congestive heart failure

(3) serum creatinine >= 2.0 mg/dL

(4) plasma cells representing >= 20% of bone marrow cellularity

(5) platelet count <= 500,000 per µL

(6) peripheral neuropathy

 

Age is a difficult risk factor to handle. Based on Figure 2, page 1064, most patients die within 0 - 5 years, with an age range of 30 to 90 and a mean age of 63 years. For patients alive >= 10 years the age range is 35 - 68 years with a mean of 54 years. However, most patients < 63 years die within 5 years. Defining long term survival as >= 10 years may favor a younger population; perhaps survival should be age adjusted for that of the general population.

 


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