Some drug toxicities (analgesic nephropathy, adriamycin cardiotoxicity, chloroquine retinopathy) are related to the total cumulative dose of the drug over time. This can be calculated based on the daily dose and duration of therapy.
grams of drug exposure =
= (milligrams of drug per day) * (number of days taken) / 1000
This can become more complex if:
(1) the daily dose has changed over time
(2) the patient has been noncompliant
(3) there have been drug-free intervals
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