The M.D. Anderson Cancer Center's Tumor Score can be used to evaluate the risk for a patient with an aggressive malignant non-Hodgkin's lymphoma at the time of presentation. This can help identify patients who may benefit from more aggressive therapy.
Parameters:
(1) Ann Arbor stage
(2) B-type symptoms
(3) tumor burden
(4) serum LDH
(5) serum beta-2-microglobulin
B-type symptoms: one or more of the following
(1) unexplained, recurrent or sustained fever, with temperature > 38°C
(2) drenching night sweats
(3) weight loss > 10% over the 6 months prior to diagnosis
"Bulky" disease - at least 1 of the following:
(1) 1 or more tumor masses >= 7 cm
(2) a mediastinal mass visible on a standing PA chest X-ray
Parameter |
Finding |
Points |
---|---|---|
Ann Arbor Stage |
III or IV |
1 |
|
I or II |
0 |
B type symptoms |
present |
1 |
|
absent |
0 |
bulky tumor burden |
present |
1 |
|
absent |
0 |
serum LDH |
>= 1.1 times the upper limit of normal (ULN) reference range |
1 |
|
< 1.1 times ULN |
0 |
serum beta-2 microglobulin |
>= 1.5 times the ULN |
1 |
|
< 1.5 times the ULN |
0 |
tumor score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• A low score is associated with a good prognosis while a high score is associated with a poor prognosis.
Score |
Prognosis |
---|---|
0, 1 or 2 |
good |
3, 4, or 5 |
poor |
Purpose: To estimate the prognosis for a patient with an aggressive lymphoma using the M.D. Anderson Cancer Center Tumor Score.
Specialty: Hematology Oncology
Objective: severity, prognosis, stage
ICD-10: C82, C83, C85,