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Risk Score for First Chronic Phase of CML (CML-CP Score)

Purpose: To evaluate a patient with CML in the first chronic phase undergoing hematopoietic stem cell transplant using the CML-CP score of Passweg et al.

Description

Passweg et al developed a risk score for a patient in the first chronic phase of CML treated by allogeneic hematopoietic stem cell transplant. It is based on the EBMT risk score. The authors are from the Chronic Leukemia Study Writing Committee of the International Bone Marrow Transplant Registry.


Parameters:

(1) age of the patient in years

(2) donor type

(3) sex-mismatch

(4) interval from the diagnosis to transplant

 

Parameter

Finding

Points

age of the patient

< 30 years

0

 

30 - 40 years

1

 

> 40 years

2

donor

HLA identical sibling

0

 

HLA matched unrelated donor

2

sex mismatch

male patient, female donor

1

 

other combination

0

interval from diagnosis to transplant

< 1 year

0

 

>= 1 year

1

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 6

• The higher the score the worse the survival.

 

Score

Probability of 5-Year Survival

0

74%

1 or 2

69%

3

54%

4

41-48%

5 or 6

23-39%

from Table IV, page 618


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Specialty

Objective

ICD-10