The Ophthalmic Medications for Tolerability (COMTOL) checklist questionnaire can be used to evaluate the nature and frequency of adverse effects during the use of an ophthalmic medication. This can be very useful in comparing different medications. The questionnaire is administered before use to give a baseline level, and then can be administered during and at the end of use.
Domains:
(1) frequency of side effects: 5, with 15 items
(2) bothersomeness of side effects: 5, with 15 items (mirror frequency domains)
(3) limitations on activities: 3, with 7 items
In addition, there are 4 global questions concerning how the person's quality of life has been affected, compliance and satisfaction with medication use.
|
Domains: Frequency of Side Effects |
Items |
|
frequency of ocular symptoms |
burning or stinging |
|
|
redness |
|
|
itchy eyes |
|
|
discharge |
|
|
swelling |
|
|
dry eyes |
|
|
tearing |
|
frequency of taste side effects |
bitter taste |
|
|
unusual taste |
|
frequency of vision difficulties |
blurred vision |
|
|
dimming of vision |
|
|
trouble seeing at night |
|
frequency of accommodation difficulties |
trouble reading |
|
|
trouble focussing near to far |
|
frequency of browache |
browache |
|
Response |
Score |
|
did not experience |
0 |
|
rarely |
1 |
|
occasionally |
2 |
|
up to half the time |
3 |
|
more than half of the time |
4 |
|
most of the time |
5 |
|
always |
6 |
|
Domains: Bothersomeness of Side Effects |
Items |
|
bothersomeness of ocular symptoms |
burning or stinging |
|
|
redness |
|
|
itchy eyes |
|
|
discharge |
|
|
swelling |
|
|
dry eyes |
|
|
tearing |
|
bothersomeness of taste side effects |
bitter taste |
|
|
unusual taste |
|
bothersomeness of vision difficulties |
blurred vision |
|
|
dimming of vision |
|
|
trouble seeing at night |
|
bothersomeness of accomodation difficulties |
trouble reading |
|
|
trouble focussing near to far |
|
bothersomeness of browache |
browache |
|
Response |
Score |
|
not at all |
0 |
|
minimal |
1 |
|
mild |
2 |
|
moderate |
3 |
|
marked |
4 |
|
extremely |
5 |
|
Domains: Limitations From Side Effects |
Items |
|
limitations on driving |
driving at night |
|
|
driving during the day |
|
limitations on reading |
reading the newspaper |
|
|
reading other than the newspaper |
|
limitations on moderate activities |
lifting or carrying groceries |
|
|
climbing 1 flight of stairs |
|
|
walking several blocks |
|
Response |
Score |
|
not at all |
0 |
|
minimal |
1 |
|
mild |
2 |
|
moderate |
3 |
|
marked |
4 |
|
extremely |
5 |
|
Global Questions |
Response |
Points |
|
side effects interfere with quality of life |
not at all |
0 |
|
|
minimal |
1 |
|
|
mild |
2 |
|
|
moderate |
3 |
|
|
marked |
4 |
|
|
extreme |
5 |
|
activity limitations interfere with quality of life |
not at all |
0 |
|
|
minimal |
1 |
|
|
mild |
2 |
|
|
moderate |
3 |
|
|
marked |
4 |
|
|
extreme |
5 |
|
frequency that one or more doses missed |
did not experience |
0 |
|
|
rarely |
1 |
|
|
occasionally |
2 |
|
|
up to half the time |
3 |
|
|
more than half the time |
4 |
|
|
most of the time |
5 |
|
|
always |
6 |
|
satisfaction with medication |
totally satisfied |
0 |
|
|
somewhat satisfied |
1 |
|
|
slightly satisfied |
2 |
|
|
slightly dissatisfied |
3 |
|
|
mostly dissatisfied |
4 |
|
|
totally dissatisfied |
5 |
Purpose: To use the the Ophthalmic Medications for Tolerability (COMTOL) checklist questionnaire to assess an ocular medication for side effects.
Specialty: Ophthalmology, Pharmacology, clinical
Objective: drug interactions, adverse effects, complication detection
ICD-10: H10-H13, H15-H22, H25-H28, H30-H36, H40-H42, H43-H45,
