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The French Five Factor Score (FFS)

Purpose: To determine the prognosis for a patient with systemic vasculitis using the French Five Factor Score (FFS).

Description

Guillevin et al developed a Five Factor Score (FFS) that can be used to predict prognosis in patients with polyarteritis nodosa, Churg-Strauss Syndrome and other systemic vasculitides. This can help identify those patients who may require more aggressive management. The authors are from the French Vasculitis Study Group.


Factors:

(1) proteinuria

(2) gastrointestinal disease

(3) renal insufficiency

(4) CNS involvement

(5) cardiomyopathy

 

Factor

Finding

Points

proteinuria

none

0

 

<= 1 gram per day

1

 

> 1 gram per day

1

gastrointestinal disease

one or more of the following: GI bleeding, perforation, infarction, pancreatitis

1

 

none of the changes

0

renal insufficiency

serum creatinine <= 1.58 mg/dL

0

 

serum creatinine > 1.58 mg/dL

1

CNS involvement

absent

0

 

present

1

cardiomyopathy

absent

0

 

present

1

 

five factor score =

= SUM(points for all 5 factors)

 

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score, the worse the prognosis.

 

FFS

Mortality Rate

0

12%

1

26%

>= 2

46%

from Table 4, page 22 Guillevin (1996); I could not find the time interval for the rate


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Specialty

Objective

ICD-10